Kevin Anderson defeated John Isner 6-3 7-6 in the Miami Masters round of 16 on hard. The upset overturned the form book — John Isner came in leading the head-to-head 9–3, defending last year's round of 32. Kevin Anderson narrowed the head-to-head to 9–4.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-02-07 | Dallas | R16 | hard | John Isner | 7-6 6-7 7-6 |
| 2018-07-02 | Wimbledon | SF | grass | Kevin Anderson | 7-6 6-7 6-7 6-4 26-24 |
| 2015-03-12 | Indian Wells Masters | R32 | hard | John Isner | 7-6 6-2 |
| 2014-08-10 | Cincinnati Masters | R64 | hard | John Isner | 6-3 6-4 |
| 2013-07-22 | Atlanta | F | hard | John Isner | 6-7 7-6 7-6 |
| 2013-02-25 | Delray Beach | QF | hard | John Isner | 6-2 7-6 |
| 2012-10-07 | Shanghai Masters | R32 | hard | John Isner | 7-6 6-7 7-6 |
| 2012-02-27 | Delray Beach | SF | hard | Kevin Anderson | 7-5 7-6 |
| 2010-07-19 | Atlanta | SF | hard | John Isner | 6-3 6-7 6-3 |
| 2010-03-11 | Indian Wells Masters | R64 | hard | John Isner | 6-3 7-5 |
| 2008-06-09 | Queen's Club | R64 | grass | John Isner | 7-6 6-4 |
| 2008-03-03 | Las Vegas | R16 | hard | Kevin Anderson | 7-6 7-5 |
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About