Mikhail Kukushkin defeated John Isner 6-4 6-7 4-6 6-1 6-4 in the Wimbledon round of 64 on grass. The upset overturned the form book — John Isner came in leading the head-to-head 4–0, defending last year's semi-final. Mikhail Kukushkin claimed a first win over John Isner in five meetings, narrowing the head-to-head to 4–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-10-29 | Paris Masters | R32 | hard | John Isner | 6-3 6-7 7-6 |
| 2017-03-06 | Indian Wells Masters | R64 | hard | John Isner | 7-6 7-6 |
| 2014-08-17 | Winston-Salem | R16 | hard | John Isner | 6-1 7-6 |
| 2014-05-26 | Roland Garros | R64 | clay | John Isner | 6-7 7-6 6-3 7-6 |
Averages over each player's completed matches in the selected window (198 vs 166). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About