Reilly Opelka defeated John Isner 7-6 7-6 6-7 7-6 in the Australian Open round of 128 on hard. The result followed the form book — Reilly Opelka came in leading the head-to-head 4–1. Reilly Opelka extended the head-to-head to 5–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2022-04-04 | Houston | F | clay | Reilly Opelka | 6-3 7-6 |
| 2022-02-07 | Dallas | SF | hard | Reilly Opelka | 7-6 7-6 |
| 2019-07-22 | Atlanta | R16 | hard | Reilly Opelka | 7-6 6-7 7-6 |
| 2019-02-11 | New York | SF | hard | Reilly Opelka | 6-7 7-6 7-6 |
| 2016-08-01 | Atlanta | SF | hard | John Isner | 6-7 6-4 6-2 |
Averages over each player's completed matches in the selected window (200 vs 166). ATP, WTA & Challenger.
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About
Per-surface Serve / Return Rating (0–100, percentile within the hard field, opponent-adjusted over 52 weeks). About