John Isner defeated Gilles Muller 6-4 6-2 in the Atlanta semi-final on hard. The result followed the form book — John Isner came in defending last year's final. John Isner extended the head-to-head to 4–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-06-16 | London | R16 | carpet | Gilles Muller | 3-6 7-6(16) 7-6(7) |
| 2016-06-13 | Queen's Club | R16 | grass | Gilles Muller | 3-6 7-6 7-6 |
| 2015-01-19 | Australian Open | R32 | hard | Gilles Muller | 7-6 7-6 6-4 |
| 2012-02-20 | Memphis | R32 | hard | John Isner | 7-6 7-6 |
| 2011-07-18 | Atlanta | SF | hard | John Isner | 7-5 6-7 6-1 |
| 2010-07-19 | Atlanta | R16 | hard | John Isner | 4-6 7-6 7-6 |
Averages over each player's completed matches in the selected window (200 vs 83). ATP, WTA & Challenger.
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About