Gilles Muller defeated Mikhail Youzhny 6-3 7-5 in the Sofia round of 16 on hard. The result followed the form book — Gilles Muller came in defending last year's semi-final. Gilles Muller extended the head-to-head to 4–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2018-03-19 | Miami Masters | R64 | hard | Mikhail Youzhny | 4-6 6-4 6-2 |
| 2016-06-20 | Nottingham | R16 | grass | Gilles Muller | 6-7 7-6 6-3 |
| 2015-06-15 | Queen's Club | R32 | grass | Gilles Muller | 6-7 6-4 7-6 |
| 2012-08-27 | US Open | R128 | hard | Gilles Muller | 2-6 3-6 7-5 7-6 7-6 |
| 2009-05-25 | Roland Garros | R128 | clay | Mikhail Youzhny | 7-6 6-1 6-4 |
| 2005-05-23 | Roland Garros | R128 | clay | Mikhail Youzhny | 6-4 6-1 6-0 |
Averages over each player's completed matches in the selected window (83 vs 86). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About