Feliciano Lopez defeated John Isner 6-7 7-6 7-6 7-5 in the Wimbledon round of 32 on grass. The upset overturned the form book — John Isner came in leading the head-to-head 6–2, defending last year's round of 64. Feliciano Lopez narrowed the head-to-head to 6–3.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2016-10-24 | Vienna | R16 | hard | John Isner | 7-6 3-6 7-6 |
| 2016-01-18 | Australian Open | R32 | hard | John Isner | 6-7 7-6 6-2 6-4 |
| 2015-06-18 | London | R16 | carpet | John Isner | 7-6(5) 6-7(9) 7-6(4) |
| 2015-06-15 | Queen's Club | R16 | grass | John Isner | 7-6 6-7 7-6 |
| 2014-10-05 | Shanghai Masters | R16 | hard | Feliciano Lopez | 6-3 6-4 |
| 2012-04-09 | Houston | SF | clay | John Isner | 6-7 7-6 6-3 |
| 2012-01-16 | Australian Open | R32 | hard | Feliciano Lopez | 6-3 6-7 6-4 6-7 6-1 |
| 2011-11-07 | Paris Masters | R16 | hard | John Isner | 6-4 6-2 |
Averages over each player's completed matches in the selected window (200 vs 200). ATP, WTA & Challenger.
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About