Wayne Odesnik defeated John Isner 7-5 3-6 7-6 in the Houston quarter-final on clay. The upset overturned the form book — John Isner came in leading the head-to-head 4–0, defending last year's round of 32. Wayne Odesnik claimed a first win over John Isner in five meetings, narrowing the head-to-head to 4–1.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2014-07-07 | Newport | R32 | grass | John Isner | 6-3 7-6 |
| 2009-07-19 | Indianapolis | QF | hard | John Isner | 7-5 6-7 7-5 |
| 2009-02-14 | Memphis | Q16 | hard | John Isner | 6-3 7-6(4) |
| 2007-07-29 | Washington | R16 | hard | John Isner | 6-7 7-6 7-6 |
Averages over each player's completed matches in the selected window (92 vs 200). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About