David Marrero advanced when Pablo Santos retired 3-1 in the Spain F21 round of 32. David Marrero extended the head-to-head to 3–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2006-03-06 | Egypt F1 | QF | clay | Pablo Santos | 6-4 6-4 |
| 2006-02-13 | Spain F6 | QF | clay | David Marrero | 7-5 5-7 7-6(5) |
| 2006-02-06 | Spain F5 | F | clay | Pablo Santos | 6-3 3-0 |
| 2004-08-23 | Spain F20 | SF | clay | David Marrero | 7-6(8) 6-2 |
Averages over each player's completed matches in the selected window. ATP, WTA & Challenger.