Amelie Mauresmo defeated Serena Williams 1-6 7-5 6-3 in the Rome semi-final on clay. The upset overturned the form book — Serena Williams came in leading the head-to-head 11–1, defending the title. Amelie Mauresmo narrowed the head-to-head to 11–2.
| Date | Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|---|
| 2008-06-23 | Wimbledon | R32 | grass | Serena Williams | 7-6 6-1 |
| 2006-08-28 | US Open | R16 | hard | Amelie Mauresmo | 6-4 0-6 6-2 |
| 2005-01-17 | Australian Open | QF | hard | Serena Williams | 6-2 6-2 |
| 2004-11-14 | Los Angeles | SF | hard | Serena Williams | 4-6 7-6(2) 6-4 |
| 2004-11-10 | WTA Tour Championships | SF | carpet | Serena Williams | 4-6 7-6 6-4 |
| 2004-06-21 | Wimbledon | SF | grass | Serena Williams | 6-7 7-5 6-4 |
| 2003-05-26 | Roland Garros | QF | clay | Serena Williams | 6-1 6-2 |
| 2003-02-03 | Paris | F | carpet | Serena Williams | 6-3 6-2 |
| 2002-06-24 | Wimbledon | SF | grass | Serena Williams | 6-2 6-1 |
| 2002-01-06 | Sydney | QF | hard | Serena Williams | 6-4 7-6 |
| 2000-02-14 | Hanover | SF | carpet | Serena Williams | 6-2 6-7 7-6 |
| 1999-02-22 | Paris | F | carpet | Serena Williams | 6-2 3-6 7-6 |
Averages over each player's completed matches in the selected window (200 vs 198). ATP, WTA & Challenger.
Performance in the biggest moments — break points, deciding sets and tiebreaks (0–100, higher is better). About
Each player's serve crossed against the other's return, converted to expected hold of serve. Recent completed matches, ATP, WTA & Challenger. About